INTERMITTENT DIETARY METHIONINE DEPRIVATION FACILITATES TUMORAL FERROPTOSIS AND SYNERGIZES WITH CHECKPOINT BLOCKADE

Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade

Abstract Dietary methionine interventions are beneficial to apoptosis-inducing chemotherapy and radiotherapy for cancer, while their effects on ferroptosis-targeting therapy and immunotherapy are unknown.Here we show the length of time methionine deprivation affects tumoral ferroptosis differently.Prolonged methionine deprivation prevents glutathio

read more

Study on distribution of advance supporting stress and stability of coal pillar during the working face passing through abandon roadway

The working face 1303 passing through the gob was studied by means of field investigation, laboratory test, theoretical analysis and numerical simulation, taking the engineering geological conditions of 1303 working face in the north wing of a mine in Datong, Shanxi Province as the background.The results show that the influence range of the leading

read more


Moderating role of observing the five precepts of Buddhism on neuroticism, perceived stress, and depressive symptoms

Purpose Evidence has shown that the Five precepts significantly affect the relationship between attachment and resilience; however, little is known whether observing the Five Precepts would help reduce depressive symptoms among those who experience risks.The aim of this study was to examine the moderating role of the Five Precepts in the mediation

read more